|
KMID : 0870519980020020156
|
|
Journal of Korean Academy of Addiction Psychiatry
1998 Volume.2 No. 2 p.156 ~ p.161
|
|
|
Pharmacotherapy of Alcoholism-Drugs Mainly Acting on the Dopamine System
|
|
Kim Si-Geun
|
|
|
Abstract
|
|
|
Subjective effects of alcohol involve multiple neurotransmitter systems and their receptors. Dopaminergic systems,
especially those found in the mesolimbic areas, seem to mediate the reinforcing action of alcohol. Dopaminergic agents,
however, have not proven as effective as first predicted. The achievement of long-term abstinence by chronic alcoholics
following detoxification presents difficulties, and there are few helpful drugs. Tiapride, a dopamine D2 antagonist, has
been reported in a number of European studies to be effective in this regard. Author reviewed the pharmacology and therapeutic potential of tiapride in the management of alcoholism.
|
|
|
KEYWORD
|
|
|
Alcoholism, Dopaminergic agents, Tiapride
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|